Lanthanide Nanoparticles Enable Continuous-wave NIR STED Microscopy
Date: 2021-07-06
Source: WLA
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Stimulated-emission depletion (STED) microscopy, invented by Stefan HELL in 2000 (laureate of 2014 Nobel Prize in Chemistry), has brought optical microscopy into the nanodimension and profoundly extended our horizons to the subcellular level.

(Credit: PicoQuant)

A research team led by Prof LIU Xiaogang from the Department of Chemistry, National University of Singapore, discovered that a series of neodymium (Nd3+)-doped lanthanide nanoparticles can act as more effective nanoprobes for STED imaging applications, enabling autofluorescence-free, low-power, super-resolution imaging in NIR optical windows.
Prof Liu said, “In recent years, many researchers have been taking on challenges in long term, deep tissue, high resolution imaging. This new generation of lanthanide nanoprobes may potentially find important applications in bioimaging and molecular detection.”